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KMID : 1143420170100370998
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Public Health Weekly Report
2017 Volume.10 No. 37 p.998 ~ p.1004
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Thyroid stimulating hormone reference range and prevalence of thyroid dysfunction in the Korean population: Korea national health and nutrition examination survey, 2013-2015
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Woo Gyeong-Ji
Kim Hye-Jin
Kim Yoon-Jung
Oh Kyung-Won
Kim Won-Gu
Kim Won-Bae
Kim Tae-Yong
Kim Sun-Wook
Chung Jae-Hoon
Shin Myung-Hee
Park Jin-Woo
Park Hai-Lin
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Abstract
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Background: No nationwide epidemiological study evaluating the prevalence of overt and subclinical forms of hypothyroidism and hyperthyroidism has yet been conducted in Korea. This study aimed to evaluate the reference range of serum thyroid stimulating hormone (TSH) and the national prevalence of thyroid dysfunctions in Korea.
Methodology: Nationwide cross-sectional data were analyzed from a representative sample of the civilian, non-institutionalized Korean population (n=6,564) who underwent blood tests for thyroid function and thyroid peroxidase antibody (TPOAb) as part of the Korea National Health and Nutrition Examination Survey (2013-2015).
Results: The reference interval of serum TSH in the Korean reference population was 0.62- 6.86 mIU/L (male 0.63-6.44 mIU/L, females 0.60-7.21 mIU/L). Based on this reference interval, the prevalence of overt and subclinical hypothyroidism was 0.73% (males 0.40%, females 1.10%) and 3.10% (males 2.26%, females 4.04%), respectively. The prevalence of hypothyroidism increased with increasing age until 50-59 years. The prevalence of overt and subclinical hyperthyroidism was 0.54% (males 0.30%, females 0.81%) and 2.98% (males 2.43%, females, 3.59%), respectively.
Conclusion: This study provides important baseline information for understanding the patterns of thyroid dysfunction in Korea.
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KEYWORD
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